Mascota has two companies who offer bus services, primarily in the middle class category. With departures for Guadalajara and Puerto Vallarta on a regular basis:

Auto Transportes Guadalajara, Talpa, Mascota SA de CV
(Commonly known as the red buses)

Auto Transportes Guadalajara, Talpa, Mascota, Ameca, Pto Vallarta, SA de CV.
Commonly known as the blue buses)

Both companies offer services to Guadalajara passing through the cross roads to Talpa, Crucero de Volcanes, Atenguillo, Mixtlan, Crucero de Guachinango, Ameca, Tala, La Venta del Astillero, until you arrive at the Old Central Bus station or the New Central station.

The cost per person to Guadalajara is $130 pesos (US $12).
The departure times are the following:

Airline service

Aerotaxis de la Bahia transports visitors to and from Puerto Vallarta. The telephone number in Mascota is 388 386 0599 or cellular 045 322 156 6437. Round trip fares are as follows